In this the inaugural season of the WOSFL the Premier Division comprises of 20 teams which would require each team to play 38 league fixtures. With the season yet to start due to the COVID-19 restrictions then clearly is unrealistic that the fixtures would be completed.
Consequently, the Premier Division has been divided into two Groups of 10 teams. Teams in the same group will play each other Home and Away, i.e. 18 fixtures. The teams in one group will play the teams in the other group once, either Home or Away, giving another 10 fixtures. The league season will therefore be reduced form 38 to 28 league fixtures.
As previously defined 7 teams will be relegated from the Premier Division at the end of the season.
| West of Scotland Football League | Premier Division 2020/21 |
| Group 1 | Group 2 |
| Auchinleck Talbot | Beith Juniors |
| Benburb | Cumbernauld United |
| Blantyre Victoria | Cumnock Juniors |
| Bonnyton Thistle | Darvel |
| Clydebank | Hurlford United |
| GLENAFTON ATHLETIC | Kilwinning Rangers |
| Irvine Meadow | Pollok |
| Kilbirnie Ladeside | Rossvale |
| Kirkintilloch Rob Roy | Rutherglen Glencairn |
| Largs Thistle | Troon |
The opening day fixtures have been published| Saturday 10th October 2020.
| PREMIER DIVISION | Match 01 | Group 1 |
| Auchinleck Talbot | v | Irvine Meadow |
| Blantyre Victoria | v | Bonnyton Thistle |
| Clydebank | v | Kilbirnie Ladeside |
| GLENAFTON ATHLETIC | v | Largs Thistle |
| Kirkintilloch Rob Roy | v | Benburb |
| PREMIER DIVISION | Match 01 | Group 2 |
| Pollok | v | Beith Juniors |
| Kilwinning Rangers | v | Cumbernauld United |
| Rossvale | v | Cumnock Juniors |
| Rutherglen Glencairn | v | Hurlford United |
| Troon | V | Darvel |
Glenafton hosted Largs Thistle in the last match before lockdown it was their last competitive game as Junior clubs. The two sides are now scheduled to meet again at Loch Park in their first competitive game as Senior clubs.
Glenafton Athletic 